I had this weird problem on a machine, whenever I logged into my citrix web interface, and clicked on a application icon it won’t launch. It shows downloading the file, but it would not do anything with the file it would just sit there. I check the file assoication for .ica and it was set correctly, but won’t launch still. Then I found that you may need to re-register the wfica32.exe again. Of course after that it worked. Hopefully anyone else who every encounters this issue just follow the steps below.
1. Drop to a command line prompt
2. Navigate to c:\program files\citrix\ica client
3. Type in the following command: wfica32 /setup
If you had any IE windows open close it all and open it back up. Then navigate to your citrix web interface and magically it’s fixed.